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연구자 상세정보

조애리
덕성여자대학교 약학대학 명예교수
  • 연구실명
    생물약제학 연구실
  • 담당자연락처
    -
  • 학력사항

    1976-1980 덕성여자대학교 약학대학 , 학사
    1980-1082 서울대학교 약학대학, 약제학 전공 , 석사
    1985-1990 미국, Rutgers 대학교 약학대학, 약제학 전공 , 박사
  • 경력사항

    2020-2022. 덕성여자대학교 일반대학원장
    2013-2015 덕성여자 대학교 약학대학 학장, 약학연구소 소장
    1996-2023 덕성여자대학교 약학대학 조교수/부교수/교수
    2015~2019 한국약제학회 부회장, 이사, 명예회장
    2019 대한약학회, 약제학 분과회 회장
    2003- present 식약처 중앙약사 심의의원/ 전문의원
    1999- 현재 보건산업진흥원,보건복지부,지식경제부 심의의원
    2014~ 2015 한국약학교육협의회 이사
    2004- 2005 Visiting Professor, MIT 화공과 Langer Lab., Boston, MA, USA
    1990- 1991 Post Doctor, Harvard Medical School, MGH, Boston, MA , USA
    1985- 1989 Research Assistant, Rutgers University, CDDRC, 약학대학, USA
  • 핵심연구분야

    - 창상치유, 반흔( scar) 형성 억제 생리활성 소재 연구
    - MPC phospholipid polymer
    - 기능성 화장품 (피부노화, 미백개선) 개발 및 평가
    - 조직공학을 이용한 인공피부 및 wound dressing 재료 개발 및 평가
  • 연구분야

    • ● 반고체(하이드로겔, W/O, O/W)

      -생리활성 물질의 피부 흡수, 대사 , 피부조직과의 결합 및 dermal bioavailability 연구
      -MPC phospholipid polymer의 피부장벽 개선, skin hydration
      -피부세포(Melanocytes, Fibroblast)로의 표적지향성약물전달시스템

    • ● 패치(막 제어형, 매트릭스형)

      -항고혈압 치료제의 경피흡수 시스템 개발
      -TTS 적용가능한 점착제 개발- 피부 자극, 독성 test

    • ● 기타 질환 모델

      -국소에 적용한 펩타이드성 생리활성 물질의 피부내 안정성 및 상처치유능 연구
      - wound healing , scar prevention 연구를 위한 animal model
      -생체이용률시험 및 생물학적 동등성시험 평가

    • ● 단백질 나노입자(protein nanoparticles)

      -Local delivery of CTGF siRNA

    • ● 마이크로입자(microparticle)

      조직공학을 이용한 인공피부 및 wound dressing 개발 및 평가
      -Development of wound dressing with Amniotic Membrane Extract

    • ● 마이크로캡슐화(microencapsulation)

      -Silver sulfadiazine의 방출제어를 위한 Alginate 미립구의 제조 및 특성 연구
      -Preparation of Alginate-Microsphere and Collagen Sponge for Controlled-Release and its application to wound dressing

    • ● 세포기반전달체

      CTGF siRNA delivery system 개발
      반흔 (scar)형성 억제 제형 개발, 평가 - Local silencing of Connective Tissue Growth Factor by siRNA/peptide improves dermal collagen arrangements

  • 대표논문,저서,특허

    ▪Stabilization of Lipid Lamellar Bilayer Structure of Stratum Corneum Modulated by Poly (2-methacryloyloxyethyl phosphorylcholine) in Relation to Skin Hydration and Skin Protection. Tissue Engineering and Regenerative Medicine, 18(6), 953-962. 2021
    ▪ Dose-dependent pro-or anti-scar-preventing responses of freeze-dried amniotic membrane extract in relation to suppression of connective tissue growth factor and α-smooth muscle actin. Journal of Pharmaceutical Investigation, 51(3), 327-336. 2021
    ▪Effect of palmitoyl-pentapeptide (Pal-KTTKS) on wound contractile process in relation with connective tissue growth factor and smooth muscle actin expression. Tissue Eng Regen Med,14(1):73-80, 2017
    ▪Inhibition of fibrotic contraction by C-phycocyanin through modulation of CTGF and ɑ-SMA expression, Tissue Eng. Regen. Med.2016;13(1):1-9, 2016.
    ▪Effect of freeze dried bovine amniotic membrane extract on full thickness wound healing, Arch Pharm Res.36(4);472-478, 2013
    ▪Optimum Scratch Assay Condition to evaluate Connective Tissue Growth Factor Expression for Anti-Scar Therapy, Arch. Pharm. Res. Vol 35, No.2, 383-388, 2012.
    ▪Evaluation of biomechanical and histological properties of corrosive chemical burns., J. Pharm. Invest. Vol 42, 165-170, 2012.
    ▪Preparation of Reproducible and Responsive Scar Model and Histology Analysis, J. Pharm. Invest. 40(1):45-49, 2010.
    ▪Gravimetric analysis and differential scanning calorimetric studies on glycerin-induced skin hydration, Arch Pharm Res 30 (11), 1489-1495, 2007.
    ▪Enhanced dermal delivery with nano particle formulation. Pro. Int. Control.Rel.Bioactive Mat., 33, 336-337, 2006.
    ▪Reversal of silver sulfadiazine-impaired wound healing by epidermal growth factor, Biomaterials 26 ,4670-4676 (2005)
    ▪Enhancing dermal matrix regeneration and Biomechanical properties of 2nd degree burn wounds by EGF impregnated collagen sponge dressing, Arch Pharm Res 28,11,1311-1316 (2005)
    ▪Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound, Arch. Pharm. Res. 26, 855-860 (2003).
    ▪Experimental approach to study the binding property of vitamin E (α-Tocopherol) during hairless mouse skin permeation study. Chem. Pharm. Bull. 49(6)659-663 (2001).
    ▪Characterization of skin permeation of vitamin C:Evaluation of physico-chemical parameters and differential scanning calorimetry, Chem. Pharm. Bull., 46(1), 174-177(1998)
    ▪Metabolism of vitamin E during skin permeation, J. Soc. Cosmetic Chemists., 47, 85-95(1996)
    ▪Evaluation for intrinsic skin permeation of unstable compounds, Chem. Pharm. Bull., 44(8), 1621-1623(1996)
  • 산학협력성과

    특허
    -Solubilization of Amniotic membrane and extraction technology: Pat. No. 10-1187423, 2012, Korea
    - Preparation of Chitosan sponge and its application on wound dressing: Pat. No. 10-11-6627, 2012, Korea
    -Preparation of solubilized collagen by employing organic solvents: Pat. No. 10-2002-0011381, 2002 Korea

    산학연구
    -Development of wound dressing with Amniotic membrane extract
    -경피흡수 시스템에 적용 가능한 국소형 점착제의 개발
    -항고혈압 치료제의 경피흡수시스템 개발

  • 보유장비

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  • 키워드

    경피흡수시스템, 피부, MPC phospholipid polymer, 생체이용률, 피부대사, 흡수, 기능성 화장품, 창상치유, 반흔형성, 기계적 강도, CTGF siRNA, EGF, dermal matrix