대학교: 중앙대학교 약학대학 약학과 (전공) 학위: 약학사
대학원: 서울대학교 약학대학(원) 물리약학전공 학위: 약학석사
대학원: 서울대학교 약학대학(원) 물리약학전공 학위: 약학박사

연도(부터~까지) 기 관 명 직위 담당분야

2020.03 ~2011.02 삼양사 중앙연구소 책임연구원 약물전달시스템 제제설계
2011.03 ~ 2020.09 삼양바이오팜 의약바이오연구소 수석연구원/팀장 약물전달시스템 제제설계
2020.10 ~ 2023.08 유영제약 중앙연구소 상무/연구소장 연구과제관리
2023.09 ~ 현재 인제대학교 제약공학과 부교수 제제학, 품질과학, 물리약학

신약 Preformulation 및 신제형 개량신약 제제설계
제너릭 및 개량신약 제제설계 및 최적화
의약품 대량생산 공정개발 (Process Development for Scale-up of Drug Products, CMC, QC)
난용성 약물의 가용화 및 체내흡수 증진 연구
초미세입자성 약물전달체 연구
생분해성/생체적합성 고분자 약물 전달체 개발 (Biocompatible Polymeric Micelle and Nanoparticles)
온도감응성 약물 전달체 연구- 하이드로 젤 연구
작용부위 표적나노전달체 연구
지속방출 제형 연구 - 서방형 마이크로입자, 서방형 액상 Depot연구
PK/BD 생체시료분석, 생동성시험 관리, 비임상 독성시험, IND filing, 대량생산공정연구
나노항암제 (Cancer nanomedicines)

<논문> 국내외 총 19편 논문 중 13편의 SCI 논문
1. Ro SY, Choi HM, Choi SH, Lee SW, Lim SJ, Tricaprin as a membrane permeability regulator: sustained small hydrophilic substance release from liposomes Journal of
2. Sang Yeob Park, Zion Kang Prakash Thapa, Yong Suk Jin, Joo Won Park, Hye Jung Lim, Jae Young Lee, Sa-Won Lee, Min-Hyo Seo, Min-Soo Kim, Seong Hoon Jeong, Development of sorafenib loaded nanoparticles to improve oral bioavailability using a quality by design approach. Int J Pharm. 20;566:229-238, 2019.
3. Seung Hwan Lee, Jun Gi Hwang, Sang Yeob Park, Hye Jung Lim, Sa-Won Lee, Min-Hyo Seo, Jae Woo Kim, Jang Hee Hong, Single-Dose Comparative Pharmacokinetics of Two Formulations of Lenalidomide 25 mg in Healthy Subjects: A Randomized Crossover Study. Adv Ther. 35(2):210-217, 2018
4. Jin Park, Seok Soon Park, Kyoung Jin Lee, Eun Jin Ju, Seol Hwa Shin, Eun Jeong Ko, Sa-Won Lee, Min Hyo Seo, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi, Docetaxel-polymeric nanoparticle enhances radiotherapeutic efficacy in human pancreatic cancer, Transl Cancer Res 7(1):60-67, 2018
5. Si Yeol Song, Kyu-pyo Kim, Seong-Yun Jeong, Jin Park, Jaesook Park, Joohee Jung, Hye Kyung Chung, Sa-Won Lee, Min Hyo Seo, Jung-shin Lee, Kyung Hae Jung, Eun Kyung Choi, Polymeric nanoparticle-docetaxel for the teatment of advanced solid tumors: phase I clinical trial and preclinical data from an orthotopic pancreatic cancer model, Oncotarget, 7(47):77348-77357, 2016.
6. Ha Na Woo, Hye Jyung Chung, Eun Jin Ju, Joohee Jung, Hye-Won Kang, Sa-Won Lee, Min-Hyo Seo, Jin Seong Lee, Jung Shin Lee, Heon Joo Park, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi, Polymeric nanoparticles containing taxanes enhance chemoradiotherapeutic efficacy in non-small cell lung cancer, Int. J. Radiation Oncology, 84(1):77-83. 2012.
7. Ha Na Woo, Hye Jyung Chung, Eun Jin Ju, Joohee Jung, Hye-Won Kang, Sa-Won Lee, Min-Hyo Seo, Jin Seong Lee, Jung Shin Lee, Heon Joo Park, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi, Preclinical evaluation of injectable sirolimus formulated with polymeric nanoparticle for cancer therapy, Int. J. Nanomedicine, 7, 1-12, 2012
8. Sa-Won Lee, Min-Hyuk Yun, Seung Wei Jeong, Chang-Hoon In, Ji-Young Kim, Min-Hyo Seo, Chaul-Min Pai, Sun-Ok Kim, Development of docetaxel-loaded intravenous formulation, Nanoxel-PM™ using polymer-based delivery system, J. Cont. Rel. 155, 262-271, 2011
9. Sa-Won Lee, Dong-Hoon Chang, Myung-Seop Shim, Bong-Oh Kim, Sun-Ok Kim, and Min-Hyo Seo, Ionically Fixed Polymeric Nanoparticles as a Novel Drug Carrier, Pharm. Res., 24(8), 1508-1516, 2007
10. Bryan Howard, Zhoinggao Gao, Sa-Won Lee, Min-Hyo Seo, and Natalya Rapoport, Ultrasound-Enhanced Chemotherapy of Drug-Resistant Breast Cancer Tumors by Micellar-Encapsulated Paclitaxel. Am. J. Drug Deliv. 4(2); 97-104, 2006
11. Eun-Jin Lee, Sa-Won Lee, Han-Gon Choi and Chong-Kook Kim, Bioavailability of Cyclosporin A dispersed in Sodium Lauryl Sulfate-Dextrin based Solid Nanospheres, Int. J. Pharm., 218, 125-131, 2001
12. Sa-Won Lee, Moon-Hee Kim and Chong-Kook Kim, Encapsulation of ethanol by spray drying technique: Effect of sodium lauryl sulfate, Int. J. Pharm., 187, 193-198 ,1999
13. Sa-Won Lee, Han-Gon Choi, Mi-Kyung Lee, Zhong-Gao Gao, In-Sook Kim and Chong-Kook Kim, Trials of in situ-gelling and mucoadhesive acetaminophen liquid suppository in human subjects, Int. J. Pharm., 174, 201-207, 1998
14. Sa-Won Lee, Han-Gon Choi, Jeong-Hill Park, and Chong-Kook Kim, Preparation and Evaluation of Dry Alcohol Containing Red Ginseng Extract, J. Ginseng Res., 24 (1), 23-28, 2000
15. Chung-Hwan Kim, Sa-Won Lee, Kyung-Mi Park, Han-Gon Choi, and Chong-Kook Kim, Preparation and Evaluation of Liquid Suppository Containing Prostaglandin E1-loaded Microemuulsion, J. Kor. Pharm. Sci., 30(3), 167-172. 2000.
16. Chong-Kook Kim, Sa-Won Lee, Han-Gon Choi, Zhong-Gao Gao, Mi-Kyung Lee, and In-Sook Kim, Bioequivalence of Two Clarithromycin Tablets, The Journal of Applied Pharmacology, 6, 219-224, 1998
17. Chong-Kook Kim, Eun-Jin Lee, Mi-Kyung Lee, Jun-Kyu Park, Hee-Jong Shin, Sa-Won Lee, Soo-Jeong Lim, Zhong-Gao Gao, In-Sook Kim, Han-Gon Choi, Bioequivalence of Cyclosporin A Hard Capsules, The Journal of Applied Pharmacology, 6(3), 296-302, 1998.
18. Chong-Kook Kim, Sa-Won Lee, Zhong-Gao Gao, Mi-Kyung Lee, In-Sook Kim, and Han-Gon Choi, Bioequivalence of Two Nilvadipine Tablet, The Journal of Applied Pharmacology, 6(3), 289-295. 1998.
19. Chong-Kook Kim, Han-Gon Choi, Sa-Won Lee, Zhong-Gao Gao, Mi-Kyung Lee, Soo-Jeong Lim, Young-Joon Park, and In-Sook Kim, Preparation and Bioequivalence Test of Acetoaminophen Liquid Suppository, The Journal of Applied Pharmacology, 6, 213-218, 1998.

<특허> 국내외 총 66건 출원 특허 중 최근 3년내 등록된 특허 31건
1. Bong Oh Kim, Kyu Jin Kyung, Sa Won Lee, AMPHIPHILIC BLOCK COPOLYMER COMPOSITION HAVING ENHANCED MICELLE STABILITY, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME, US 11,179,466 B2 (Nov. 23, 2021, Registered)
2. Sang Yeob Park, Hye Jung Lim, Sa Won Lee, Min Hyo Seo, ORAL TABLET FORMULATION OF LENALIDOMIDE, US 11,077,099 B2 (Aug. 3, 2021, Registered)
3. LEE, Sa-Won CHO, Joong-Woong KIM, Gyeong-Hae SEO, Min-Hyo, COMPOSITION OF AN AQUEOUS SOLUTION OF POLYMERIC NANOPARTICLES AND METHOD FOR PREPARING SAME, EP 2 792 348 B1 (14.10.2020, Registered)
4. Sa Won Lee, Gyeong Hae Kim, Min Hyo Seo, POLYMER NANOPARTICLE FREEZE-DRIED PRODUCT, AND PREPARATION METHOD THEREFOR, US 10,765,753 B2 (Sep. 8, 2020, Registered)
5. CHO, Joong-Woong KIM, Gyeong-Hae SEO, Min-Hyo LEE, Sa-Won Daejeon 34083 (KR), STABILIZED PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING SAME, EP 3 305 283 B1 (02.09.2020, Registered)
6. Seo, Min-Hyo; Lee, Sa-Won, Polymeric micelle composition containing a poorly soluble drug and preparation method of the same, EP 2 201 935 B1 (08.07.2020, Registered)
7. Joong-Woong Cho, Gyeong -Hae Kim, Min-Hyo Seo, Sa-Won Lee, STABILIZED PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING SAME, US 10,456,362 B2 (Oct. 29, 2019, Registered)
8. SEO, Min Hyo LEE, Sa Won KIM, Do Hoon COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING, EP 2 658 539 B1 (04.09.2019, Registered)
9. Joong-Woong Cho, Gyeong-Hae Kim, Min -Hyo Seo, Sa -Won Lee, PHARMACEUTICAL COMPOSITION NOT CONTAINING ANTIOXIDANT AND PREPARATION METHOD THEREFOR, US 10,300,063 B2 (May 28, 2019 Registered)
10. Sa-Won LEE, Do-Hoon KIM, Bong-Oh KIM, Min-Hyo SEO, “SUSTAINED-RELEASE POLYMERIC MICROPARTICLES CONTAINING POORLY WATER-SOLUBLE DRUG AND METHOD FOR PREPARING THE SAME” PCT/KR11/10030 (2011-12-23 filed)
11. Min-Hyo SEO, Sa-Won LEE, Do-Hoon KIM, “COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING” PCT/KR11/9908 (2011-12-21 filed)
12. Hey-Won KANG, Min-Hyo SEO, Sa-Won LEE, Bong-Oh KIM, Eun-Kyung Choi, Seong-Yoon Jeong, Hana Woo, “An injectable composition comprising polymeric nanoparticles containing rapamycin with an improved water solubility and a method for preparing the same, and an anticancer composition comprising the same for a combination therapy with radiation” PCT/KR2010/009476호 (2010.12.29 filed)
13. Sa-Won LEE, Min-Hyo SEO, “AMPHIPHILIC BLOCK COPOLYMER MICELLE COMPOSITION CONTAINING TAXANE AND MANUFACTURING PROCESS OF THE SAME” PCT/KR2008/6021 (2008-10-13filed)
14. Sa-Won LEE, Min-Hyo SEO, Myung-Han HYUN, Dong-Hoon CHANG, Jeong-Il YU, Jeong-Kyung KIM, Hye-Jeong YOON, “Polymeric composition for drug delivery” PCT/KR03/02259 (2003.10.24 filed)
15. Yil-Woong YI, Sa-Won LEE, Jeong-Il YU, Dong-Hoon CHANG, Min-Hyo SEO, Hye-Won KANG, Jae-Hong Kim, “Delivery system for bioactive agents on the basis of a polymeric drug carrier comprising amphiphilic block polymer and a polylactic acid erivative” PCT/KR05/01330 (2005.11.17 filed), EP1742665 (2007.01.17 registered)
16. Min-Hyo SEO, Bong-Oh KIM, In-Ja CHOI, Myung-Seob SHIM, Sa-Won LEE, Myung-Han HYUN, Jung-Il YU, Dong-Hoon CHANG, Jeong-Kyung KIM, Hye-Jeong YOON, “Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery”, PCT/KR04/02583 (2004. 10. 08 filed), US2004-962204 (2004.10.07 filed), EP1670838 (2006. 06. 21 registered)
17. Min-Hyo SEO, Sa-Won LEE, Hee-Jo KIM, Jeong-Kyung KIM, Myung-Han HUYN, Jeong-Il Yu, “Polymeric micelle composition with improved stability” PCT/KR02/01942 (2002.10.17 filed), US2002-493043 (2002.10.17 filed), EP1448707 (2004.08.25 registered)

<학술회의> 국내외 학술회의 구두발표 또는 포스터 발표 총 45건 발표
1. 이사원, Polymer-based nanomedicines for treatment of cancer, 한국약제학회 국제학술대회, The K Hotel서울 가야금홀, 2019.11.22 구두발표,
2. 이사원, Polymeric micelle-based nanomedicines for treatment of cancer, Asia Pacific Consortium of Gene and Cell Therapy (APCGCT) 연례총회 및 학술대회, Hanyang Institute of Technology (HIT) center, 2019.11.8 구두발표
3. 이사원, Research trends in polymeric nanocarriers for drug delivery systems, 대한약학회 추계국제학술대회 물리약학분과 심포지움, Yeosu Expo Convention Center, 2019.10.15 구두발표
4. H. J. Lim, I. J. Choi, J. Y. Lee, M. H. Yun, S. W. Cho, S. W. Jeong, J. Y. Kim, S. W. Lee Development of Oral Solid Dosage Form for Sunitinib Free Base with Improved pH-Dependent Dissolution Rate and Absorption, AAPS PharmSci360, November 3–6, 2019, Henry B. Gonzalez Convention Center, San Antonio, Texas, USA
5. 이사원, 김종국, 분무건조법을 이용한 덱스트린 피막내 에탄올 봉입에 미치는 황산 라우릴 나트륨(SLS)의 영향 평가, 대한약학회, 1995.10.27-28 (성균관대 약대)

보건복지부 보건의료기술 진흥사업 (2004 5~2006.3, 16.7억원, 참여연구원 실무책임자)
보건복지부 혁신형 연구중심병원사업 (2006 12~2011 11, 25.6억원, 참여연구원 실무책임자)
보건복지부 보건의료연구개발사업 (2009 12~2011 11, 8.93억원, 연구책임자)
보건복지부 혁신형제약기업 국제공동연구지원사업 (2014 10~2016 9, 16.68억원, 연구책임자)
사업자원부 산업핵심기술개발사업 (2017 3~ 2019.12, 56.3억원, 참여연구원)

● Microfulidics장비

● High Pressure Homogenizer

● Rotary Tabletting Machine

● Dissolution Tester

● Particle Size Analyzer (DLS)

● HPLC

● 초임계유체장비

● UV spectrometer

● Spray Dryer

● Rotary Evaporator

고분자나노입자, 약물전달, 고체분산체, 펩타이드경구흡수, 프리포뮬레이션, 나노항암제, 제제설계, 설계기반품질고도화, 가용화, 용해도, 고분자미셀, 표적약물전달